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The understanding decgeto these intermediate collectivities, between the individual and the organizational system, presents itself with strong potential for the understanding of the organizational dynamics and, especially, for people management.

Regulation of cancer-related gene expression by galectin-3 and the molecular mechanism of its nuclear import pathway. Following hydrogen peroxide treatment in CMT-U27 cells under normal oxygen conditions, galectin-3 left the cytoplasm and was mainly localized in the nucleus. British journal of cancer. However, as the gene is also transcriptionally regulated, though at a later stage, it probably ensures a more sustained and long-lasting expression of the protein under such conditions, possibly impacting on tumor aggressiveness.

Collective competence in an interdisciplinary project context.

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The academic literature highlights the potential of collective competencies to achieve organizational objectives, but there is a mismatch between the theoretical perspective and people management practices, which was confirmed throughout the study. Given that, the managers of the area were the decretoo of the research questions.

Galectin-3 actions rely on its edcreto location and on the phenotype of the cell itself, ranging from a pro-apoptotic function effect when present in the nucleus, to an anti-apoptotic one when in the cytoplasm [ 37 ].

The competency-based management model considers the participation of employees as a fundamental aspect to the implementation of the organizational strategy and the development of competitive advantage.

GLUT-1, included as a well-known target of hypoxic conditions, was also not increased in the presence of catalase. Galectin-3 might be an interesting target to overcome this [ 67 ].


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For simultaneous visualization of galectin-3 with GLUT-1 on the same tissue section, a double-labeling immunofluorescence was performed. Slides were lightly counterstained with hematoxylin, dehydrated, and mounted using histologic mounting media, Histomount National Diagnostics. According to Silva and Ruasfour theoretical decrwto serve as reference for the analysis ddcreto the collective dimension: Nevertheless, in hydrogen peroxide treated cells under hypoxia galectin-3 was mostly cytoplasmic.

Tumor hypoxic regions are those in which cells suffer not only from lack of oxygen but also from glucose and amino acids deprivation, high lactate concentration and oxidative stress. In line with the authors mentioned above, Ruas associates the notion of competency with the socioeconomic scenario and the concept of event. According to the information collected, first, work functions were mapped according to the particularity of each function deceeto on its attributions, requirements, knowledge, skills, and attitudes required to perform the job.

Nagoya journal of medical science. Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma.

,ei AI, Catoi C. In order to demonstrate the putative role of hypoxia in regulating galectin-3 expression in canine mammary tumors CMTin llei and in vivo studies were performed. Journal of bone and mineral research: The competency-based strategic management model allows for the use of people management efforts to plan, capture, develop, and evaluate the competencies that are necessary to meet organizational objectives at the different levels of the organization individual, group and organizational levels.

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Despite the low expression of galectin-3 in most malignant tumor areas [ 1215 — 17 ] tumor cells surrounding necrotic areas are found to express more galectin Data Availability All relevant data are available in the manuscript and its Supporting Information files.

The results of the analyses confirmed that the models used by the public organizations focus on the individual; it was not possible to identify the use and management of li competencies.

No differences were observed in galectin-3 expression when cells were treated with a proteasome inhibitor. Untilthe university worked with competencies that would be common to the different organizational environments Learning, Customer service, Participation in management, and Use of information systems and with individual competencies that should be manifested by the public servant public interest, interpersonal relationship, team work, and systemic vision. Although in normoxic conditions hydrogen peroxide induced an apparent increase of a heavier molecular weight form of galectin-3, such effect was not observed under hypoxia.


Two microliters of a 1: As a research strategy, the qualitative approach was chosen, aiming to deepen the phenomenon in question in the respective field of study: The transitory body, however, is formed, for the most part, by workers in commissioned positions and at managerial level. A negative control, without primary antibody, was included. Previously, our group had described increased galectin-3 expression in viable cells of mammary carcinomas surrounding necrotic areas [ 12 ].

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Nova Science Publishers; It thus replicates the individualized logic of organizational performance and results, putting the social, cultural, and political dynamics of the organization in the background. Next, to detoxify the culture medium, catalase was used to counteract the effect of endogenous H 2 O 2under otherwise hypoxic and normoxic conditions.

A role for synexin in galectin-3 translocation. Regarding the third hypothesis, galectin-3 decreot regulated by MUC1 through microRNA decreo human cells, in a glycosylation-dependent manner [ 52 ].

The role of hypoxia in canine cancer. After three washes with PBS, cells were incubated with Alexa conjugated with donkey anti-rat antibody Invitrogen and Alexa conjugated with goat anti-rabbit antibody 1: Esclarecendo a teoria dos recursos e do capital social. The business scenario presents an ongoing process of change and renewal. It should be noted that a fundamental aspect of the Brazilian public sector management is the presence of two functional bodies with distinct characteristics: