ARIXTRA PRESCRIBING INFORMATION PDF

ARIXTRA PRESCRIBING INFORMATION PDF

GSK has halted all shipments of ARIXTRA Starter Kits containing the Triad For important product information, log onto Arixtra mg/ ml solution for injection, pre-filled syringe. 2. .. Detailed information on this medicinal product is available on the website of the European . Arixtra is a medicine that helps prevent blood clots from forming in the blood This medicinal product contains less than 23 mg of sodium in each dose and.

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Optimal timing between administration of fondaparinux and neuraxial procedures not known. Anticoagulant effects may persist for 2—4 days following discontinuance of therapy in patients with normal renal function i.

History of serious hypersensitivity reaction e. Patients should be sitting or supine during administration. Dosage of fondaparinux sodium is expressed in terms of the salt. Risk increased by use of indwelling epidural catheters or by concomitant use of drugs affecting hemostasis e.

Binds selectively to antithrombin III; unable to inactivate thrombin. Latex-containing devices; user labeling. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism. Comparison of fondaparinux and enoxaparin in acute coronary syndromes.

Discontinue platelet-aggregation inhibitors prior to initiation of fondaparinux 1 Print this page Add to My Med List. ACCP recommends fondaparinux as an option for thromboprophylaxis in acutely ill, hospitalized medical patients at increased risk of thrombosis.

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Arixtra Monograph for Professionals –

If coadministration is essential, monitor patients closely 1 Postoperative wound infection, postoperative hemorrhage, fever, surgical site reaction, anemia, hypertension, pneumonia, vomiting. N Engl J Med. Clin Appl Thromb Hemost. Bounameaux, H, Perneger T. Food and Drug Administration.

Several antithrombotic agents e. Amended economic impact analysis of final rule requiring use of labeling on natural rubber containing devices.

Avoid concomitant use of drugs that increase risk of bleeding unless essential for management of underlying condition e. Subscribe to free Drugs. Patients undergoing abdominal surgery: Has been administered at an initial dose of 2. Importance of infromation fondaparinux and immediately contacting a clinician if a serious allergic reaction e. Importance of advising patients who have had neuraxial anesthesia or spinal puncture to monitor for manifestations of spinal or epidural hematoma e.

Importance of informing patients that concomitant use of aspirin or other NSAIAs can increase risk of bleeding, and to discontinue use of these drugs whenever possible.

VTE, thrombophilia, antithrombotic therapy, and pregnancy: Anticoagulation results from rapid inhibition of factor Xa by antithrombin III bound to fondaparinux about fold greater than innate activity.

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Dosages for fondaparinux sodium and heparin, heparinoids, or LMWHs cannot be used interchangeably on a unit-for-unit or mg-for-mg basis 1 as they differ in the manufacturing process, anti-factor Xa and antithrombin activity, and dosage. Discontinue platelet-aggregation inhibitors prior to initiation of fondaparinux 1 40 If coadministration is essential, monitor patients closely 1 A synthetic pentasaccharide for the prevention of deep- vein thrombosis.

Monitor frequently for manifestations of neurologic impairment and treat urgently if neurologic compromise noted. Eliminated unchanged in urine in individuals with normal renal function.

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Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after hip- fracture surgery. Some packaging components e. If coadministration is essential, monitor patients closely Lovenox enoxaparin sodium injection prescribing information. Risk also increased by history of traumatic or repeated epidural or spinal puncture, spinal deformity, or spinal surgery.

Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: Synthetic pentasaccharides do not cause platelet activation by antiheparin-platelet factor 4 antibodies.

Hull R, Pineo G. FDA alerts for all medications.

Arixtra fondaparinux sodium injection prescribing information. Discontinue oral anticoagulants prior to initiation of fondaparinux 1 40 If coadministration is essential, monitor patients closely 1 The pharmacokinetics of fondaparinux sodium in healthy volunteers. Consider potential benefits versus risks of spinal or epidural anesthesia or spinal puncture in patients infformation or being orescribing for thromboprophylaxis with anticoagulants.

Arixtra Rating 5 User Reviews 8. Postoperative fondaparinux versus preoperative enoxaparin for prevention of venous thromboembolism in elective hip-replacement surgery: Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Constipation, headache, insomnia, fever, nausea, urinary tract infection, coughing.